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Isoniazid Toxicity - Symptoms and Treatment

Isoniazid is an antimicrobial that has been used as a first-line agent for prophylaxis and treatment of tuberculosis since 1952. Tuberculosis is an infectious diseased caused by a bacterium. Once the infection is acquired, it usually remains dormant in the lungs. Later, the infection may become active in the lungs and sometimes spreads throughout the body.

Patients with a tuberculosis skin test that has recently become abnormal (demonstrating recent infection with tuberculosis) but a normal chest x-ray (demonstrating inactive infection) are given INH alone for 6-9 months. Patients with active disease are put on a regimen of INH combined with other antituberculous medications. Because of errors in dosage or intentional overdose, life-threatening toxicity may result.

Causes of Isoniazid Toxicity

Find common causes and risk factors of Isoniazid Toxicity:

  • Alcoholism .
  • HIV/AIDS epidemic.
  • Emergence of multi drug resistant tuberculosis .
  • Homelessness.
  • Overcrowded conditions .









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